CNS-Met COBRE
About
The University of Kentucky Phase I Center of Research in central nervous system metabolism is supported by a $10.6 million, five-year award (P20 GM148326) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.
The central nervous system (CNS) has a very high requirement for energy which results in high metabolism rates. As such, CNS metabolism and neuronal excitability are interdependent, and disruptions of CNS metabolism are implicated in numerous neurological disease states, including Alzheimer’s Disease, Parkinson’s disease, epilepsy, ischemia, and traumatic CNS injury, but the mechanisms and underlying connections between CNS metabolism and disease are not well-defined. The ºÃÉ«ÏÈÉú has made significant investments over the past decade in investigators with strong metabolic and metabolomics expertise and instrumentation to support research efforts, which has greatly enhanced existing strongholds in neuroscience, cancer, cardiovascular, diabetes, and obesity research. The goal of our multidisciplinary Center of Biomedical Research Excellence (COBRE) focused on CNS Metabolism (CNS-Met) is a strategically designed, sustainable framework that promotes leading-edge research focused on the role of metabolic mediators of brain function and disease, with an emphasis on encouraging research excellence from Junior Research Project Leaders. To accomplish these goals, we will meet four specific aims: (1) develop a critical mass of funded investigators with research programs directly related to the COBRE’s unifying theme; (2) provide strong team-based mentoring combining basic and clinical expertise; (3) recruit new investigators to the COBRE in multidisciplinary areas of neurologic dysfunction through pilot project grant and recruitment of junior Research Project Leaders; and (4) create synergy among research projects via critical links to strong research centers and core facilities at ºÃÉ«ÏÈÉú, including existing COBREs. Overall, the CNS-Met will create a critical mass of scientists who are skilled and well-equipped to foster a sustainable research center focused on CNS metabolism.
Use the following sentence to cite the COBRE award in your COBRE work:
"This publication (or project) was made possible by the University of Kentucky CNS Metabolism (CNS-Met) COBRE, supported by a grant from the National Institute of General Medical Sciences – NIGMS (P20 GM148326) from the National Institutes of Health."
Recent Publications
Publications 1 – 9
1: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S, Morganti JM, Gordon SM, Johnson LA. APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses. Neurobiol Dis. 2025 Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. Epub 2025 May 30. PMID: 40451545; PMCID: PMC12187248.
2: Velmurugan GV, Prajapati S, Tran S, Miller C, Burke B, Hubbard WB. Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals. Exp Neurol. 2025 Oct;392:115325. doi: 10.1016/j.expneurol.2025.115325. Epub 2025 May 30. PMID: 40451452; PMCID: PMC12302826.
3: Vekaria HJ, Shelley SJ, Messmer SJ, Kunjadia PD, McLouth CJ, Sullivan PG, Fraser JF, Pennypacker KR, Pandya CD. Sex- and Tissue-Specific Effects of Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic Stroke. Biomolecules. 2025 May 20;15(5):738. doi: 10.3390/biom15050738. PMID: 40427631; PMCID: PMC12109232.
4: Ostrakhovitch EA, Song ES, Stegemann JE, McLeod M, Yamasaki TR. Effect of hydrogen sulfide on alpha-synuclein aggregation and cell viability. Sci Rep. 2025 May 4;15(1):15597. doi: 10.1038/s41598-025-99794-z. PMID: 40320462; PMCID: PMC12050307.
5: Maeda N, Taylor LS, Nassar-Guifarro M, Monawar MS, Dunn SM, Devanney NA, Li F, Johnson LA, Kayashima Y. Genomic and cellular context-dependent expression of the human ELMO1 gene transcript variants. Gene. 2025 Jun 20;954:149438. doi: 10.1016/j.gene.2025.149438. Epub 2025 Mar 25. PMID: 40147730; PMCID: PMC12147996.
6: Ostrakhovitch EA, Ono K, Yamasaki TR. Metabolomics in Parkinson's Disease and Correlation with Disease State. Metabolites. 2025 Mar 18;15(3):208. doi: 10.3390/metabo15030208. PMID: 40137172; PMCID: PMC11944848.
7: Constantino NJ, Carroll CM, Williams HC, Vekaria HJ, Yuede CM, Saito K, Sheehan PW, Snipes JA, Raichle ME, Musiek ES, Sullivan PG, Morganti JM, Johnson LA, Macauley SL. ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. Epub 2025 Feb 18. PMID: 39964713; PMCID: PMC11874466.
8: Velmurugan GV, Vekaria HJ, Patel SP, Sullivan PG, Hubbard WB. Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging. J Cereb Blood Flow Metab. 2024 Dec 12:271678X241306054. doi: 10.1177/0271678X241306054. Epub ahead of print. PMID: 39668588; PMCID: PMC11638933.
9: Sims SL, Frazier HN, Case SL, Lin RL, Trosper JN, Vekaria HJ, Sullivan PG, Thibault O. Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose. NPJ Metab Health Dis. 2024;2(1):33. doi: 10.1038/s44324-024-00037-y. Epub 2024 Nov 8. PMID: 39524535; PMCID: PMC11549053.
Publications 1 – 9
1: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S, Morganti JM, Gordon SM, Johnson LA. APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses. Neurobiol Dis. 2025 Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. Epub 2025 May 30. PMID: 40451545; PMCID: PMC12187248.
2: Velmurugan GV, Prajapati S, Tran S, Miller C, Burke B, Hubbard WB. Sex-dependent blood-brain barrier alterations following repeated mild blast traumatic brain injury at varying inter-injury intervals. Exp Neurol. 2025 Oct;392:115325. doi: 10.1016/j.expneurol.2025.115325. Epub 2025 May 30. PMID: 40451452; PMCID: PMC12302826.
3: Vekaria HJ, Shelley SJ, Messmer SJ, Kunjadia PD, McLouth CJ, Sullivan PG, Fraser JF, Pennypacker KR, Pandya CD. Sex- and Tissue-Specific Effects of Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic Stroke. Biomolecules. 2025 May 20;15(5):738. doi: 10.3390/biom15050738. PMID: 40427631; PMCID: PMC12109232.
4: Ostrakhovitch EA, Song ES, Stegemann JE, McLeod M, Yamasaki TR. Effect of hydrogen sulfide on alpha-synuclein aggregation and cell viability. Sci Rep. 2025 May 4;15(1):15597. doi: 10.1038/s41598-025-99794-z. PMID: 40320462; PMCID: PMC12050307.
5: Maeda N, Taylor LS, Nassar-Guifarro M, Monawar MS, Dunn SM, Devanney NA, Li F, Johnson LA, Kayashima Y. Genomic and cellular context-dependent expression of the human ELMO1 gene transcript variants. Gene. 2025 Jun 20;954:149438. doi: 10.1016/j.gene.2025.149438. Epub 2025 Mar 25. PMID: 40147730; PMCID: PMC12147996.
6: Ostrakhovitch EA, Ono K, Yamasaki TR. Metabolomics in Parkinson's Disease and Correlation with Disease State. Metabolites. 2025 Mar 18;15(3):208. doi: 10.3390/metabo15030208. PMID: 40137172; PMCID: PMC11944848.
7: Constantino NJ, Carroll CM, Williams HC, Vekaria HJ, Yuede CM, Saito K, Sheehan PW, Snipes JA, Raichle ME, Musiek ES, Sullivan PG, Morganti JM, Johnson LA, Macauley SL. ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. Epub 2025 Feb 18. PMID: 39964713; PMCID: PMC11874466.
8: Velmurugan GV, Vekaria HJ, Patel SP, Sullivan PG, Hubbard WB. Astrocytic mitochondrial transfer to brain endothelial cells and pericytes in vivo increases with aging. J Cereb Blood Flow Metab. 2024 Dec 12:271678X241306054. doi: 10.1177/0271678X241306054. Epub ahead of print. PMID: 39668588; PMCID: PMC11638933.
9: Sims SL, Frazier HN, Case SL, Lin RL, Trosper JN, Vekaria HJ, Sullivan PG, Thibault O. Variable bioenergetic sensitivity of neurons and astrocytes to insulin and extracellular glucose. NPJ Metab Health Dis. 2024;2(1):33. doi: 10.1038/s44324-024-00037-y. Epub 2024 Nov 8. PMID: 39524535; PMCID: PMC11549053.
Publications 10 – 18
10: Velmurugan GV, Vekaria HJ, Hartz AMS, Bauer B, Hubbard WB. Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries. Fluids Barriers CNS. 2024 Oct 15;21(1):81. doi: 10.1186/s12987-024-00579-9. PMID: 39407313; PMCID: PMC11476969.
11: Banadaki MD, Rummel NG, Backus S, Butterfield DA, St Clair DK, Campbell JM, Zhong W, Mayer K, Berry SM, Chaiswing L. Extraction of redox extracellular vesicles using exclusion-based sample preparation. Anal Bioanal Chem. 2024 Nov;416(28):6317-6331. doi: 10.1007/s00216-024-05518-z. Epub 2024 Sep 7. Erratum in: Anal Bioanal Chem. 2024 Dec;416(29):7187-7188. doi: 10.1007/s00216-024-05568-3. PMID: 39243301; PMCID: PMC11807383.
12: Kalimon OJ, Vekaria HJ, Prajapati P, Short SL, Hubbard WB, Sullivan PG. The Uncoupling Effect of 17β-Estradiol Underlies the Resilience of Female-Derived Mitochondria to Damage after Experimental TBI. Life (Basel). 2024 Jul 30;14(8):961. doi: 10.3390/life14080961. PMID: 39202703; PMCID: PMC11355196.
13: Johnson LA, Macauley SL. Alzheimer's and metabolism wed with IDO1. Science. 2024 Aug 23;385(6711):826-827. doi: 10.1126/science.adr5836. Epub 2024 Aug 22. PMID: 39172856; PMCID: PMC11661799.
14: Mobilia M, Karakashian A, Neupane KR, Hage O, Whitus C, Carter A, Voy C, Johnson LA, Graf GA, Gordon SM. Enhancement of high-density lipoprotein- associated protease inhibitor activity prevents atherosclerosis progression. Atherosclerosis. 2024 Sep;396:118544. doi: 10.1016/j.atherosclerosis.2024.118544. Epub 2024 Jul 16. PMID: 39126769; PMCID: PMC11404725.
15: Krizan I, Solingapuram Sai KK, Damuka N, Macauley SL, Maria Thurman B, Long M, Kavanagh K. Exploratory Dual PET imaging of 18F] fluorodeoxyglucose and 11C]acetoacetate in type 2 diabetic nonhuman primates. Bioorg Med Chem Lett. 2024 Oct 1;111:129906. doi: 10.1016/j.bmcl.2024.129906. Epub 2024 Jul 25. PMID: 39059565; PMCID: PMC11403582.
16: Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024 Sep;20(9):6590-6605. doi: 10.1002/alz.13877. Epub 2024 Jul 19. PMID: 39031528; PMCID: PMC11497726.
17: Kalantar GH, Saraswat S, SantaCruz-Calvo S, Gholamrezaeinejad F, Javidan A, Agrawal M, Liu R, Kern PA, Zhang XD, Nikolajczyk BS. Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes. Nutrients. 2024 May 7;16(10):1404. doi: 10.3390/nu16101404. PMID: 38794641; PMCID: PMC11124302.
18: Valentine Y, Nikolajczyk BS. T cells in obesity-associated inflammation: The devil is in the details. Immunol Rev. 2024 Jul;324(1):25-41. doi: 10.1111/imr.13354. Epub 2024 May 20. PMID: 38767210; PMCID: PMC11694249.
Publications 10 – 18
10: Velmurugan GV, Vekaria HJ, Hartz AMS, Bauer B, Hubbard WB. Oxidative stress alters mitochondrial homeostasis in isolated brain capillaries. Fluids Barriers CNS. 2024 Oct 15;21(1):81. doi: 10.1186/s12987-024-00579-9. PMID: 39407313; PMCID: PMC11476969.
11: Banadaki MD, Rummel NG, Backus S, Butterfield DA, St Clair DK, Campbell JM, Zhong W, Mayer K, Berry SM, Chaiswing L. Extraction of redox extracellular vesicles using exclusion-based sample preparation. Anal Bioanal Chem. 2024 Nov;416(28):6317-6331. doi: 10.1007/s00216-024-05518-z. Epub 2024 Sep 7. Erratum in: Anal Bioanal Chem. 2024 Dec;416(29):7187-7188. doi: 10.1007/s00216-024-05568-3. PMID: 39243301; PMCID: PMC11807383.
12: Kalimon OJ, Vekaria HJ, Prajapati P, Short SL, Hubbard WB, Sullivan PG. The Uncoupling Effect of 17β-Estradiol Underlies the Resilience of Female-Derived Mitochondria to Damage after Experimental TBI. Life (Basel). 2024 Jul 30;14(8):961. doi: 10.3390/life14080961. PMID: 39202703; PMCID: PMC11355196.
13: Johnson LA, Macauley SL. Alzheimer's and metabolism wed with IDO1. Science. 2024 Aug 23;385(6711):826-827. doi: 10.1126/science.adr5836. Epub 2024 Aug 22. PMID: 39172856; PMCID: PMC11661799.
14: Mobilia M, Karakashian A, Neupane KR, Hage O, Whitus C, Carter A, Voy C, Johnson LA, Graf GA, Gordon SM. Enhancement of high-density lipoprotein- associated protease inhibitor activity prevents atherosclerosis progression. Atherosclerosis. 2024 Sep;396:118544. doi: 10.1016/j.atherosclerosis.2024.118544. Epub 2024 Jul 16. PMID: 39126769; PMCID: PMC11404725.
15: Krizan I, Solingapuram Sai KK, Damuka N, Macauley SL, Maria Thurman B, Long M, Kavanagh K. Exploratory Dual PET imaging of 18F] fluorodeoxyglucose and 11C]acetoacetate in type 2 diabetic nonhuman primates. Bioorg Med Chem Lett. 2024 Oct 1;111:129906. doi: 10.1016/j.bmcl.2024.129906. Epub 2024 Jul 25. PMID: 39059565; PMCID: PMC11403582.
16: Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024 Sep;20(9):6590-6605. doi: 10.1002/alz.13877. Epub 2024 Jul 19. PMID: 39031528; PMCID: PMC11497726.
17: Kalantar GH, Saraswat S, SantaCruz-Calvo S, Gholamrezaeinejad F, Javidan A, Agrawal M, Liu R, Kern PA, Zhang XD, Nikolajczyk BS. Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes. Nutrients. 2024 May 7;16(10):1404. doi: 10.3390/nu16101404. PMID: 38794641; PMCID: PMC11124302.
18: Valentine Y, Nikolajczyk BS. T cells in obesity-associated inflammation: The devil is in the details. Immunol Rev. 2024 Jul;324(1):25-41. doi: 10.1111/imr.13354. Epub 2024 May 20. PMID: 38767210; PMCID: PMC11694249.
Publications 19 – 28
19: Taylor CE, Mendenhall LE, Sunshine MD, Wilson JN, Calulot CM, Sun RC, Johnson LA, Alilain WJ. Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions. J Neurophysiol. 2024 Jul 1;132(1):23-33. doi: 10.1152/jn.00255.2023. Epub 2024 May 15. PMID: 38748407; PMCID: PMC11918448.
20: Constantino NJ, Carroll CM, Williams HC, Yuede CM, Sheehan PW, Andy Snipes J, Musiek ES, Johnson LA, Macauley SL. Kir6.2-K ATP channels alter glycolytic flux to modulate cortical activity, arousal, and sleep-wake homeostasis. bioRxiv [Preprint]. 2024 Feb 28:2024.02.23.581817. doi: 10.1101/2024.02.23.581817. Update in: Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. PMID: 38464274; PMCID: PMC10925108.
21: Hubbard WB, Velmurugan GV, Sullivan PG. The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury. Neurochem Int. 2024 Mar;174:105680. doi: 10.1016/j.neuint.2024.105680. Epub 2024 Feb 3. PMID: 38311216; PMCID: PMC10922998.
22: Kilgore MO, Hubbard WB. Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging. Int J Mol Sci. 2024 Jan 4;25(1):642. doi: 10.3390/ijms25010642. PMID: 38203813; PMCID: PMC10779081.
23: Burke BI, Goh J, Albathi FA, Valentino TR, Nolt GL, Joshi JK, Dungan CM, Johnson LA, Wen Y, Ismaeel A, McCarthy JJ. ApoE isoform does not influence skeletal muscle regeneration in adult mice. Front Physiol. 2023 Nov 22;14:1302695. doi: 10.3389/fphys.2023.1302695. PMID: 38074327; PMCID: PMC10702509.
24: Ren Y, Wang X, Zhang S, Hu H, Quicksall Z, Lee S, Morganti JM, Johnson LA, Asmann YW, Zhao N. Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain. Sci Rep. 2023 Oct 6;13(1):16855. doi: 10.1038/s41598-023-44183-7. PMID: 37803069; PMCID: PMC10558435.
25: Kalimon OJ, Vekaria HJ, Velmurugan GV, Hubbard WB, Sullivan PG. Characterizing Sex Differences in Mitochondrial Dysfunction After Severe Traumatic Brain Injury in Mice. Neurotrauma Rep. 2023 Sep 25;4(1):627-642. doi: 10.1089/neur.2023.0046. PMID: 37752924; PMCID: PMC10518693.
26: Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging Dis. 2024 Aug 1;15(4):1688-1725. doi: 10.14336/AD.2023.0814. PMID: 37611907; PMCID: PMC11272209.
27: Hubbard WB, Vekaria HJ, Velmurugan GV, Kalimon OJ, Prajapati P, Brown E, Geisler JG, Sullivan PG. Mitochondrial Dysfunction After Repeated Mild Blast Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug. J Neurotrauma. 2023 Nov;40(21-22):2396-2409. doi: 10.1089/neu.2023.0102. Epub 2023 Aug 25. PMID: 37476976; PMCID: PMC10653072.
28: Ruggiero AD, Vemuri R, Blawas M, Long M, DeStephanis D, Williams AG, Chen H, Justice JN, Macauley SL, Day SM, Kavanagh K. Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design. Geroscience. 2023 Oct;45(5):2785-2803. doi: 10.1007/s11357-023-00830-5. Epub 2023 Jun 1. PMID: 37261678; PMCID: PMC10643765.
Publications 19 – 28
19: Taylor CE, Mendenhall LE, Sunshine MD, Wilson JN, Calulot CM, Sun RC, Johnson LA, Alilain WJ. Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions. J Neurophysiol. 2024 Jul 1;132(1):23-33. doi: 10.1152/jn.00255.2023. Epub 2024 May 15. PMID: 38748407; PMCID: PMC11918448.
20: Constantino NJ, Carroll CM, Williams HC, Yuede CM, Sheehan PW, Andy Snipes J, Musiek ES, Johnson LA, Macauley SL. Kir6.2-K ATP channels alter glycolytic flux to modulate cortical activity, arousal, and sleep-wake homeostasis. bioRxiv [Preprint]. 2024 Feb 28:2024.02.23.581817. doi: 10.1101/2024.02.23.581817. Update in: Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. PMID: 38464274; PMCID: PMC10925108.
21: Hubbard WB, Velmurugan GV, Sullivan PG. The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury. Neurochem Int. 2024 Mar;174:105680. doi: 10.1016/j.neuint.2024.105680. Epub 2024 Feb 3. PMID: 38311216; PMCID: PMC10922998.
22: Kilgore MO, Hubbard WB. Effects of Low-Level Blast on Neurovascular Health and Cerebral Blood Flow: Current Findings and Future Opportunities in Neuroimaging. Int J Mol Sci. 2024 Jan 4;25(1):642. doi: 10.3390/ijms25010642. PMID: 38203813; PMCID: PMC10779081.
23: Burke BI, Goh J, Albathi FA, Valentino TR, Nolt GL, Joshi JK, Dungan CM, Johnson LA, Wen Y, Ismaeel A, McCarthy JJ. ApoE isoform does not influence skeletal muscle regeneration in adult mice. Front Physiol. 2023 Nov 22;14:1302695. doi: 10.3389/fphys.2023.1302695. PMID: 38074327; PMCID: PMC10702509.
24: Ren Y, Wang X, Zhang S, Hu H, Quicksall Z, Lee S, Morganti JM, Johnson LA, Asmann YW, Zhao N. Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain. Sci Rep. 2023 Oct 6;13(1):16855. doi: 10.1038/s41598-023-44183-7. PMID: 37803069; PMCID: PMC10558435.
25: Kalimon OJ, Vekaria HJ, Velmurugan GV, Hubbard WB, Sullivan PG. Characterizing Sex Differences in Mitochondrial Dysfunction After Severe Traumatic Brain Injury in Mice. Neurotrauma Rep. 2023 Sep 25;4(1):627-642. doi: 10.1089/neur.2023.0046. PMID: 37752924; PMCID: PMC10518693.
26: Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging Dis. 2024 Aug 1;15(4):1688-1725. doi: 10.14336/AD.2023.0814. PMID: 37611907; PMCID: PMC11272209.
27: Hubbard WB, Vekaria HJ, Velmurugan GV, Kalimon OJ, Prajapati P, Brown E, Geisler JG, Sullivan PG. Mitochondrial Dysfunction After Repeated Mild Blast Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug. J Neurotrauma. 2023 Nov;40(21-22):2396-2409. doi: 10.1089/neu.2023.0102. Epub 2023 Aug 25. PMID: 37476976; PMCID: PMC10653072.
28: Ruggiero AD, Vemuri R, Blawas M, Long M, DeStephanis D, Williams AG, Chen H, Justice JN, Macauley SL, Day SM, Kavanagh K. Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design. Geroscience. 2023 Oct;45(5):2785-2803. doi: 10.1007/s11357-023-00830-5. Epub 2023 Jun 1. PMID: 37261678; PMCID: PMC10643765.